Since the publication of the benchmark first edition of this book, chemical library and combinatorial chemistry methods have developed into mature technologies. There have also been significant shifts in emphasis in combinatorial synthesis. Reflecting the growth in the field and the heightened focus on select areas, Analytical Methods in Combinatorial Chemistry, Second Edition updates a classic text and captures the current state of these technologies.
Written by leaders in the field, this second edition includes several enhancements. A chapter on high-throughput analytical methods and informatics reflects the demand for quality control of library members. A new chapter focuses on high-throughput purification methods. All chapters have been updated with new data.
Topics discussed in this second edition include:
- Properties of solid-phase samples, analytical studies targeted to understand these properties, and resin swelling
- Fourier Transform Infrared techniques
- On-support mass spectrometry and nuclear magnetic resonance methods used in the reaction optimization stage
- Combinatorial library analysis using spectrophotometric, fluorometric, and other methods
- Quality control of combinatorial libraries
- High-throughput purification methods
- Future directions and analytical challenges
The coming decade is sure to usher in a new wave of progress in this critical field. This volume provides not only an analysis of the recent developments in analytical methods, technologies and applications; it also provides a window on future possibilities.
Über den Autor Bing Yan
![]()
Bing Yan obtained his doctorate from Changchun Institute of Applied Chemistry, Chinese Academy of Sciences in 1998. He continued his research as a research assistant and postdoctoral fellow at the City University of Hong Kong, Peking University and the University of Sherbrooke from 1998 to 2001. Since November 2001, he has been a professor of chemistry at Tongji University, China. His current interests focus on rare earth chemistry and photofunctional materials, including rare earth inorganic/organic molecular luminescent hybrids; rare earth functional compounds and micro-nano solid materials; and rare earth crystal framework hybrid systems. As a corresponding author, he has published over 400 research papers in international journals.
